HCID 13533221, compound → 5-(Chloroacetyl)-8-hydroxy-2(1H)-quinolinone

Participants

Reaction Steps

1.7 g of the 5-chloroacetyl-8-chloroacetoxycarbostyril (VI) obtained in Example 5 was added to 50 ml of 10% aqueous hydrochloric acid followed by stirring at 95° to 100° C. for 2 hours. After cooling, the precipitated crystals were filtered, washed with water and then recrystallized from methanol to obtain 1.1 g of 5-chloroacetyl-8-hydroxycarbostyril (IV) having a melting point of 285°-286° C. (with decomposition) as pale yellow crystals.

Provenance & Evidence