Hydrochloric Acid → 5-(Chloroacetyl)-8-hydroxy-2(1H)-quinolinone

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Reaction Steps

2.5 g of the 5-chloroacetyl-8-chloroacetoxycarbostyril (VI) obtained in Example 5 was added to 30 ml of 5% aqueous potassium hydroxide followed by stirring at 20° to 25° C. for 30 minutes. The resulting solution was adjusted to a pH of 2 to 3 with diluted hydrochloric acid while cooling. The precipitated crystals were filtered, washed with water and recrystallized from methanol to obtain 1.7 g of 5-chloroacetyl-8-hydroxycarbostril (IV) having a melting point of 285°-287° C. (with decomposition) as pale yellow crystals.

Provenance & Evidence