Hydrochloric Acid → HCID 13195286, compound

Participants

Reaction Steps

12.6 g of the 5-chloroacetyl-8-hydroxycarbostyril (IV) obtained in Example 4 or 8 was suspended in 130 ml of isopropanol, and 2515 g of isopropylamine (III) was added dropwise to the resulting suspension while stirring. The reaction mixture was then stirred at 55° to 60° C. for 3 hours. After cooling, concentrated hydrochloric acid was added to the mixture to adjust the mixture to a pH of 2 to 3, and the precipitated crystals were filtered, washed with acetone and recrystallized from methanol-dimethylformamide (1:1 by volume) to obtain 6.5 g of 5-isopropylaminoacetyl-8-hydroxycarbostyril (II) hydrochloride having a melting point of 286° - 288° C. (with decomposition as pale yellow crystals.

Provenance & Evidence