Hydrochloric Acid → HCID 13533222, compound

Participants

Reaction Steps

4.3 g of the 5-chloroacetyl-8-hydroxycarbostyril (IV) obtained in Example 4 or 8 was suspended in 50 ml of ethanol, and 5 g of sec-butylamine was added dropwise to the resulting suspension while stirring followed by stirring at 60° to 65° C. for 5 hours. After cooling, the resulting mixture was adjusted to a pH of 3 with concentrated hydrochloric acid. The precipitated crystals were filtered, washed with acetone and recrystallized from methanol-ethanol (1:1 by volume) to obtain 2.9 g of 5-sec-butylaminoacetyl-8-hydroxycarbostyril (II) hydrochloride having a melting point of 289° - 291° C. (with decomposition) as pale yellow crystals.

Provenance & Evidence