Ammonia → HCID 53842883, compound

Participants

Reaction Steps

33.3 g. of 4-chloro-2-methyl-6-(4-methyl-1-piperazinyl)-5-nitropyridine-3-carboxylic acid ethyl ester (0.1 mol) are dissolved in about 100 ml. of alcohol. 50 ml. of aqueous ammonia solution (30%) are added and the mixture is heated in an autoclave at 80° for 10 hours. After this time, the solution is evaporated to dryness and the residue is extracted with hot alcohol. On cooling, 25.2 g. of 4-amino-2-methyl-6-(4-methyl-1-piperazinyl)-5-nitropyridine-3-carboxylic acid ethyl ester precipitate, (78%), m.p. 73°-75° (methanol).

Provenance & Evidence