6-Chloro-4[(1,1-dimethylethyl)amino]-2-methyl-5-nitropyridine-3-carboxylic acid ethyl ester → 4-Amino-6-chloro-2-methyl-5-nitropyridine-3-carboxylic acid ethyl ester

Participants

Reaction Steps

31.6 g. of 6-chloro-4[(1,1-dimethylethyl)amino]-2-methyl-5-nitropyridine-3-carboxylic acid ethyl ester (0.1 mol.) are heated with stirring at 250°-260° for 5 minutes. The dark oil is cooled to room temperature and 50 ml. of methyl alcohol are added. 18.2 g. of 4-amino-6-chloro-2-methyl-5-nitropyridine-3-carboxylic acid ethyl ester crystallize on cooling (70%), m.p. 89-91° (methanol).

Provenance & Evidence