HCID 21436337, compound → 7-{3-[2-(1-Hydroxycyclohexyl)ethyl]-4-oxo-1,3-thiazolidin-2-yl}heptanoic acid

HRID 2397619Notes

Reaction equation

HRID 2397619 reaction equation
[OH:1][CH:2]([CH2:21][CH2:22][CH2:23][CH2:24][CH3:25])[CH2:3][CH2:4][N:5]1[C:9](=[O:10])[CH2:8][S:7][CH:6]1[CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][C:17]([O:19]C)=[O:18].OC1(CCN2C(=O)CSC2CCCCCCC(OC)=O)CCCCC1>>[OH:1][C:2]1([CH2:3][CH2:4][N:5]2[C:9](=[O:10])[CH2:8][S:7][CH:6]2[CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][C:17]([OH:19])=[O:18])[CH2:25][CH2:24][CH2:23][CH2:22][CH2:21]1

Participants

3

Reactant 2

HCID 21436337HCID 21436337, compoundHCID 21436338HCID 21436338, compound

Product 1

HCID 214363217-{3-[2-(1-Hydroxycyclohexyl)ethyl]-4-oxo-1,3-thiazolidin-2-yl}heptanoic acid

Procedure

This compound is prepared essentially by the same method as described in Example 1, Step C, except that the methyl 7-[3-(3-hydroxyoctyl)-4-oxo-2-thiazolidinyl]heptanoate is replaced by methyl 7-{3-[2-(1-hydroxycyclohexyl)ethyl]-4-oxo-2-thiazolidinyl}heptanoate. Chromatographic purification of the crude product resulting from this method gives the title compound as a tlc homogeneous, viscous oil.

Workup

  1. customThis compound is prepared essentially by the same method
  2. customChromatographic purification of the crude product
  3. customresulting from this method

Sources & evidence

ORD record
ord-c9e551d9c7c9493b8522910932a43b1a
Source dataset
uspto-grants-1977_05
Patent number
US04022794

Reaction notes

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