HCID 70624972, compound → HCID 20321574, compound

HRID 2397657Notes

Reaction equation

HRID 2397657 reaction equation
P(O)(O)(O)=O.[Cl:6][C:7]1[CH:8]=[C:9]([C:19]([C:22]2[N:26]([CH3:27])[N:25]=[CH:24][C:23]=2[CH2:28][NH2:29])=[CH:20][CH:21]=1)[C:10]([C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=1[F:18])=O>[OH-].[Na+].C(Cl)Cl>[Cl:6][C:7]1[CH:21]=[CH:20][C:19]2[C:22]3[N:26]([CH3:27])[N:25]=[CH:24][C:23]=3[CH2:28][N:29]=[C:10]([C:12]3[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=3[F:18])[C:9]=2[CH:8]=1

Participants

4

Reactant 1

HCID 70624972HCID 70624972, compound

Product 1

HCID 20321574HCID 20321574, compound

Reagents, catalysts & solvents 2

HCID 6344DichloromethaneSolventHCID 14798Sodium HydroxideSolvent

Procedure

The suspension of 0.5 g of 3-chloro-6-(1-methyl-4-aminomethyl-5-pyrazolyl)-2'-fluorobenzophenone monophosphate in 20 ml of 0.5N aqueous sodium hydroxide and 50 ml of methylene chloride is shaken for 5 min., the organic layer separated, dried and evaporated, to yield the 8-chloro-6-(2-fluorophenyl)-1-methyl-1H,4H-pyrazolo[4,3-d](2)benzazepine melting at 128°; it is identical with that obtained according to Example 2.

Workup

  1. customthe organic layer separated
  2. customdried
  3. customevaporated

Sources & evidence

ORD record
ord-55c7b6ffe4ae441d8261dc79b13df610
Source dataset
uspto-grants-1977_05
Patent number
US04022801

Reaction notes

Loading…