Ethylenediamine → HCID 178484973, compound

HRID 2397721Notes

Reaction equation

HRID 2397721 reaction equation
ClC[C:3]1[N:8]=[CH:7]C=[CH:5][N:4]=1.C(N)C[NH2:11].[N:13]1[CH:18]=[CH:17][CH:16]=[N:15][C:14]=1[CH2:19][NH:20][CH2:21][CH2:22][NH2:23].CN=C=S>>[C:5]([NH:4][C:3]([NH:8][CH3:7])=[N:23][CH2:22][CH2:21][NH:20][CH2:19][C:14]1[N:15]=[CH:16][CH:17]=[CH:18][N:13]=1)#[N:11]

Participants

5

Reactant 4

HCID 3301EthylenediamineHCID 11167Methyl isothiocyanateHCID 128773712-(Chloromethyl)pyrimidineHCID 20557649N-(2-pyrimidylmethyl)ethylenediamine

Product 1

HCID 178484973HCID 178484973, compound

Procedure

Reaction of 2-chloromethylpyrimidine with ethylenediamine by the procedure of Example 34 and reaction of the resulting N-(2-pyrimidylmethyl)ethylenediamine with methyl isothiocyanate by the procedure of Example 3(b) gives, after concentrating and chromatographing, N-methyl-N'-[2-(2-pyrimidylmethylamino)ethyl]thiourea. This thiourea is reacted with lead cyanamide by the procedure of Example 3(b) to give the title compound.

Workup

  1. customgives
  2. concentrationafter concentrating
  3. customThis thiourea is reacted with lead cyanamide by the procedure of Example 3(b)

Sources & evidence

ORD record
ord-7c0963ff1a654d7da5091e079f3e10da
Source dataset
uspto-grants-1977_05
Patent number
US04022797

Reaction notes

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