Ethylamine → N-cyano-N'-ethyl-N"-[2-(2-thiazolylmethylthio)ethyl]guanidine

HRID 2397734Notes

Reaction equation

[C:1]([NH:3][C:4](=[N:7][CH2:8][CH2:9][S:10][CH2:11][C:12]1[S:13][CH:14]=[CH:15][N:16]=1)SC)#[N:2].[NH2:17][CH2:18][CH2:19]SCC1SC=CN=1.C(N)C>>[C:1]([NH:3][C:4]([NH:17][CH2:18][CH3:19])=[N:7][CH2:8][CH2:9][S:10][CH2:11][C:12]1[S:13][CH:14]=[CH:15][N:16]=1)#[N:2]

Participants

Reactant 3

HCID 6341Ethylamine

HCID 129234032-[(Thiazol-2-yl)methylthio]ethylamine

HCID 20427996N-cyano-N'-[2-(2-thiazolylmethyl-thio)ethyl]-S-methylisothiourea

Product 1

HCID 54127424N-cyano-N'-ethyl-N"-[2-(2-thiazolylmethylthio)ethyl]guanidine

Procedure

Reaction of N-cyano-N'-[2-(2-thiazolylmethylthio)ethyl]-S-methylisothiourea, prepared from 2-[(2-aminoethyl)thiomethyl]thiazole by the procedure of Example 3(c)(i), with ethylamine by the procedure of Example 4 gives N-cyano-N'-ethyl-N"-[2-(2-thiazolylmethylthio)ethyl]guanidine.

Sources & evidence

ORD record: ord-431ff637f64b40ccb46cf5ca167c0ee6
Source dataset: uspto-grants-1977_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04022797

Reaction notes

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