Ethylamine → N-cyano-N'-ethyl-N"-[2-(3-isothiazolylmethylthio)ethyl]guanidine

HRID 2397747Notes

Reaction equation

S1C=CC(CS[CH2:8][CH2:9][NH:10][C:11](=[NH:14])SC)=N1.[NH2:15][CH2:16][CH2:17][S:18][CH2:19][C:20]1[CH:24]=[CH:23][S:22][N:21]=1.[CH2:25]([NH2:27])C>>[C:25]([NH:14][C:11]([NH:10][CH2:9][CH3:8])=[N:15][CH2:16][CH2:17][S:18][CH2:19][C:20]1[CH:24]=[CH:23][S:22][N:21]=1)#[N:27]

Participants

Reactant 3

HCID 6341Ethylamine

HCID 129515372-{[(1,2-Thiazol-3-yl)methyl]sulfanyl}ethan-1-amine

HCID 178504043HCID 178504043, compound

Product 1

HCID 54273441N-cyano-N'-ethyl-N"-[2-(3-isothiazolylmethylthio)ethyl]guanidine

Procedure

Reaction N-cyano-N'-[2-(3-isothiazolylmethylthio)ethyl-S-methylisothiourea, prepared from 3-[(2-aminoethyl)thiomethyl]isothiazole by the procedure of Example 3(c)(i), wth ethylamine by the procedure of Example 4 gives N-cyano-N'-ethyl-N"-[2-(3-isothiazolylmethylthio)ethyl]guanidine.

Sources & evidence

ORD record: ord-70719160c1e244a6aa479017988fb2fa
Source dataset: uspto-grants-1977_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04022797

Reaction notes

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