2-(3-Aminopropyl)thiooxazole → HCID 178512198, compound

HRID 2397755Notes

Reaction equation

HRID 2397755 reaction equation
[NH2:1][CH2:2][CH2:3][CH2:4][S:5][C:6]1[O:7][CH:8]=[CH:9][N:10]=1.CS[C:13](=[NH:18])[NH:14][N+:15]([O-:17])=[O:16]>>[N+:15]([NH:14][C:13]([NH:1][CH2:2][CH2:3][CH2:4][S:5][C:6]1[O:7][CH:8]=[CH:9][N:10]=1)=[NH:18])([O-:17])=[O:16]

Participants

3

Reactant 2

HCID 205501192-(3-Aminopropyl)thiooxazoleHCID 135927615N-Nitro-S-methylisothiourea

Product 1

HCID 178512198HCID 178512198, compound

Procedure

Reacting 2-(3-aminopropylthio)oxazole with S-methyl-N-nitroisothiourea by the procedure of Example 2(ii) gives N-nitro-N'-[3-(2-oxazolyl)thiopropyl]guanidine. Similarly, reaction of the same starting material with N,S-dimethyl-N'-nitroisothiourea by the procedure of Example 2(iii) gives N-methyl-N'-nitro-N"-[3-(2-oxazolyl)thiopropyl]guanidine.

Sources & evidence

ORD record
ord-c6738db7e06f4789824b1b551c7b20cc
Source dataset
uspto-grants-1977_05
Patent number
US04022797

Reaction notes

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