Ethylenediamine → HCID 178484974, compound

HRID 2397761Notes

Reaction equation

HRID 2397761 reaction equation
[CH2:1]([NH2:4])[CH2:2][NH2:3].Cl[CH2:6][C:7]1[S:8][CH:9]=[CH:10][N:11]=1.[C:12]([NH:14][C:15](=[N:18][CH3:19])SC)#[N:13]>>[C:12]([NH:14][C:15]([NH:18][CH3:19])=[N:3][CH2:2][CH2:1][NH:4][CH2:6][C:7]1[S:8][CH:9]=[CH:10][N:11]=1)#[N:13]

Participants

4

Reactant 3

HCID 3301EthylenediamineHCID 1111031-Cyano-2,3-dimethylisothioureaHCID 140908642-(Chloromethyl)-1,3-thiazole

Product 1

HCID 178484974HCID 178484974, compound

Procedure

Reacting ethylendiamine with 2-chloromethylthiazole by the procedure of Example 34, then reacting the resulting N-(2-thiazolymethyl)ethylenediamine with N-cyano-N',S-dimethylisothiourea by the procedure of Example 3(a), gives N-cyano-N'-methyl-N"-[2-(2-thiazolylmethylamino)ethyl]guanidine. Hydrolysis of this compound by the procedure of Example 3(e) gives N-methyl-N'-[2-(2-thiazolylmethylamino)ethyl]guanidine trihydrochloride.

Sources & evidence

ORD record
ord-f679272eb3bd4ffbb9616e3813d28be0
Source dataset
uspto-grants-1977_05
Patent number
US04022797

Reaction notes

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