HCID 21425449, compound → HCID 21425443, compound

Participants

Reaction Steps

700 grams of 2-(3-fluorophenyloxy)-5-trifluoromethylbenzoic acid were dissolved in 3,000 milliliters of concentrated sulfuric acid whereby the temperature rose to 60 degrees Centigrade. The mixture was stirred at 45- 50 degrees Centigrade for one hour and then poured onto 10 liters of crushed ice. The precipitate was filtered off, suspended in 1,000 milliliters of acetone, made alkaline with concentrated aqueous ammonia and reprecipitated with ice and water to a volume of 10 liters. The precipitate was filtered, washed with water and dried in vacuum, whereupon it was recrystallized to yield 167 grams of 2-trifluoromethyl-6-fluoroxanthen-9-one which melts at 140- 142 degrees Centigrade.

Provenance & Evidence