Sulfuric Acid → 2-Amino-4-chloropyridin-3-ol

HRID 2397840Notes

Reaction equation

HRID 2397840 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][N:5]=[C:4]([NH:8][N+]([O-])=O)[CH:3]=1.S(=O)(=O)(O)[OH:13].NC1C([N+]([O-])=O)=C(Cl)C=CN=1>>[NH2:8][C:4]1[C:3]([OH:13])=[C:2]([Cl:1])[CH:7]=[CH:6][N:5]=1

Participants

4

Reactant 3

HCID 1118Sulfuric AcidHCID 40716944-Chloro-3-nitropyridin-2-amineHCID 13040387HCID 13040387, compound

Product 1

HCID 214366972-Amino-4-chloropyridin-3-ol

Procedure

The reaction of 4-chloro-2-nitraminopyridine with concentrated sulfuric acid at 40° gives, according to Example I-2, 2-amino-4-chloro-3-nitropyridine. The procedure of Example I-2 is then followed with this intermediate to give 2-amino-4-chloro- 3-pyridinol.

Workup

  1. customgives

Sources & evidence

ORD record
ord-3dee309a5df641588e23c73906863629
Source dataset
uspto-grants-1977_05
Patent number
US04022897

Reaction notes

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