Bromine → 2-Amino-5-bromo-4-fluoropyridin-3-ol

HRID 2397843Notes

Reaction equation

HRID 2397843 reaction equation
[NH2:1][C:2]1[C:7]([OH:8])=[C:6]([F:9])[CH:5]=[CH:4][N:3]=1.[Br:10]Br>>[NH2:1][C:2]1[C:7]([OH:8])=[C:6]([F:9])[C:5]([Br:10])=[CH:4][N:3]=1

Participants

3

Reactant 2

HCID 24408BromineHCID 214366942-Amino-4-fluoropyridin-3-ol

Product 1

HCID 214366732-Amino-5-bromo-4-fluoropyridin-3-ol

Procedure

When 2-amino-4-fluoro-3-pyridinol and bromine in a 1:1 molar ratio are passed through a glass tube heated at 350°, and the exit gases condensed and distilled, there is obtained 2-amino-5-bromo-4-fluoro-3-pyridinol.

Workup

  1. temperatureheated at 350°
  2. customthe exit gases condensed
  3. distillationdistilled

Sources & evidence

ORD record
ord-0b290a49377b4edf86b6b4a7816a1b38
Source dataset
uspto-grants-1977_05
Patent number
US04022897

Reaction notes

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