HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium amide → 2-Amino-5-fluoro-3-hydroxy-4-picoline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium amide | HCID 24533 | — |
| Reactant | 2-Nitramino-5-fluoro-4-picoline | HCID 21436676 | — |
| Reactant | 5-Fluoro-4-methylpyridin-2-amine | HCID 22063670 | — |
| Product | 2-Amino-5-fluoro-3-hydroxy-4-picoline | HCID 21436668 | — |
Reaction Steps
When 3-amino-4-picoline is subjected to diazotization in fluoboric acid as in Example I-1, there is obtained 3-fluoro-4-picoline. Treatment of the latter intermediate with sodium amide as in Example I-1, gives 2-amino-5-fluoro-4-picoline. Following the procedure of Example I-15, but substituting 2-nitramino-5-fluoro-4-picoline, there is obtained 2-amino-5-fluoro-4-methyl-3-pyridinol.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04022897 |
| Source dataset | uspto-grants-1977_05 |
| ORD ID | ord-e378e522988748669335e6028b0ba3bc |
| Source note | uspto-grants-1977_05 |