Acetic Acid → HCID 21436701, compound

Participants

Reaction Steps

When a mixture of 189.0 g of 2-amino-5-bromo-2-pyridinol and 130.0 g of methyl 2-aminocrotonate is heated for 4 hours at an internal temperature of about 150°, a solid reaction product is formed. This solid is suspended in 2 liters of chloroform and 240 ml of water, and 20% aqueous acetic acid is added to adjust the aqueous phase to pH 5.5. The chloroform solution is separated, washed with saturated aqueous sodium chloride, dried, and concentrated to give 180.5 g of 7-bromo-9-hydroxy-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one.

Provenance & Evidence