2,4-Dichlorobenzyl chloride → HCID 12219984, compound

Participants

Reaction Steps

To a solution of 6.6 g of potassium hydroxide (85%) and 10.3 g of sodium bromide in 100 ml of water and 150 ml of methanol is added, in portions, 17.6 g of 9-hydroxy-2-methyl-4H-pyrido[ 1,2-a]pyrimidin-4-one and the mixture stirred for 0.25 hours. To this is then added 19.6 g of 2,4-dichlorobenzyl chloride dissolved in 50 ml of 95% ethanol and the mixture stirred and refluxed for about 6 hours. The mixture is concentrated to dryness in vacuo and the residue is distributed between 500 ml of chloroform and 250 ml of water. Workup of the chloroform solution yields 9-[ (2,4-dichlorobenzyl)oxy]-2-methyl-4H-pyrido[ 1,2-a]-pyrimidin-4-one, m.p. 180°-182° after recrystallization from acetonitrile.

Provenance & Evidence