1-Bromo-2-methylpropane → HCID 21436660, compound

Participants

Reaction Steps

To a stirred suspension of 1.6 g of powdered sodium hydroxide in 100 ml of pure ethyl methyl ketone is added 21. g of 7-chloro-9-hydroxy-2-methyl-4H-pyrido[1,2-a] pyrimidin-4-one. The mixture is stirred for about 1 hour and 1.5 g of isobutyl bromide dissolved in 10 ml of pure ethyl methyl ketone is added dropwise. Subsequently, 0.2 g of copper bronze is added and the mixture stirred and heated under reflux for 2 hours. The mixture is cooled, diluted with 20 ml of water, filtered, and the organic phase in the filtrate separated, washed with saturated aqueous sodium chloride, dried, and concentrated to give 7-chloro-9-(isobutoxy)-2-methyl-4H-pyrido[ 1,2-a] pyrimidin-4-one.

Provenance & Evidence