反应详情

DMAMP 118 g (1 mole) and commercial grade caprylic acid 131 g (1 mole) were dissolved in 35 ml of toluene. The mixture was heated under reflux at about 140°-165° until 20 ml distillate was recovered and no more was being collected. The pressure was then reduced to 10mm and distillation was continued to about 130° C to strip off toluene and water. The pressure was then reduced to about 1 mm and the main product fraction was recovered at a liquid temperature of about 106°-109°. There was obtained 2-dimethylamino-2-methyl-1-propyl caprylate, neutral equivalent 247.9 compared with theoretical 244.

1. temperatureThe mixture was heated
2. temperatureunder reflux at about 140°-165° until 20 ml distillate
3. customwas recovered
4. customno more was being collected
5. distillationThe pressure was then reduced to 10mm and distillation
6. customwas continued to about 130° C
7. customthe main product fraction was recovered at a liquid temperature of about 106°-109°