Water → HCID 21436781, compound

Participants

Reaction Steps

To a stirred solution of 5.3 g (0.024 mole) of 7 -methoxy-3-phenylbenzofuran in 200 ml of acetic acid is added dropwise 3.3 g (0.036 mole) of dinitrogen tetroxide in 20 ml of acetic acid. After about 90 minutes the mixture is poured into cold water, precipitating a gum which is isolated by filtration and dissolved in diethyl ether. The ether solution is washed with water and saturated sodium chloride solution and dried. Evaporation gives a residue which is dissolved in chloroform and eluted through a silica gel column with chloroform. Early fractions are a yellow solid which is recrystallized from ethanol to give yellow crystals of 7-methoxy-2-nitro-3-phenylbenzofuran, m.p. 160°-161° C.

Provenance & Evidence