HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,3-Cyclohexanedione → 2-Amino-4-(biphenyl-2-yl)-1,4,5,6,7,8-hexahydro-5-oxoquinoline-3-carboxylic acid ethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,3-Cyclohexanedione | HCID 10434 | — |
| Reactant | (1,1'-Biphenyl)-2-carboxaldehyde | HCID 121052 | — |
| Reactant | Carbamimidoyl-acetic acid ethyl ester | HCID 4599837 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 2-Amino-4-(biphenyl-2-yl)-1,4,5,6,7,8-hexahydro-5-oxoquinoline-3-carboxylic acid ethyl ester | HCID 12391115 | 45% |
Reaction Steps
Upon heating a solution of 6.1 g of biphenyl-2 -aldehyde, 3.8 g of cyclohexane-1,3-dione and 5.1 g of amidinoacetic acid ethyl ester in 100 ml of ethanol for 1 hour, 2 -amino-4-(biphenyl-2-yl)-1,4,5,6,7,8-hexahydro-5-oxoquinoline- 3-carboxylic acid ethyl ester of melting point 248° C. (ethanol) is obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04022898 |
| Source dataset | uspto-grants-1977_05 |
| ORD ID | ord-317cae9adc8e45a3a0da5275f39d0e90 |
| Source note | uspto-grants-1977_05 |