HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,3-Cyclohexanedione → HCID 70635049, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,3-Cyclohexanedione | HCID 10434 | — |
| Reactant | m-Formylbenzonitrile | HCID 90670 | — |
| Reactant | Carbamimidoyl-acetic acid ethyl ester | HCID 4599837 | — |
| Reactant | N,N-dimethylformamide ethanol | HCID 19794673 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | HCID 70635049 | HCID 70635049 | 56% |
Reaction Steps
Heating a solution of 6.5 g of 3-cyanobenzaldehyde, 5.6 g of cyclohexane-1,3-dione and 6.5 g of amidinoacetic acid ethyl ester in 100 ml of ethanol for 6 hours yields 2-amino- 4-(3-cyanophenyl)-1,4,5,6,7,8-hexahydro-5-oxoquinoline-3-carboxylic acid ethyl ester of melting point 262° C. (ethanol/dimethylformamide). Yield: 56% of theory.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04022898 |
| Source dataset | uspto-grants-1977_05 |
| ORD ID | ord-6c40e35015af4ffa9208e8e41e8bf6da |
| Source note | uspto-grants-1977_05 |