Methyl p-toluenesulfonate → HCID 12596828, compound

Participants

Reaction Steps

5-Nitroisoquinoline (25 g) and methyl p-toluenesulfonate (26.8 g) were dissolved in dimethylformamide (80 ml) and allowed to stand at room temperature for three days. If a crystalline cake had not formed at the end of this time, the solution was either seeded or scratched to initiate precipitation of the product. The supernatant was decanted and ethyl acetate was added to this until no more precipitation was evident. This precipitate was collected by filtration and combined with the first precipitate. The product was recrystallized from ethanol-ethyl acetate to yield 43.9 g of yellow crystals, m.p. 144°-144.7°C.

Provenance & Evidence