p-Anisoyl chloride → HCID 8763095, compound

HRID 2397929Notes

Reaction equation

HRID 2397929 reaction equation
[C:1](Cl)(=[O:10])[C:2]1[CH:7]=[CH:6][C:5]([O:8][CH3:9])=[CH:4][CH:3]=1.[NH2:12][C:13]1[CH:22]=[CH:21][CH:20]=[C:19]2[C:14]=1[CH:15]=[CH:16][N:17]=[CH:18]2>>[CH3:9][O:8][C:5]1[CH:6]=[CH:7][C:2]([C:1]([NH:12][C:13]2[CH:22]=[CH:21][CH:20]=[C:19]3[C:14]=2[CH:15]=[CH:16][N:17]=[CH:18]3)=[O:10])=[CH:3][CH:4]=1

Participants

3

Reactant 2

HCID 7477p-Anisoyl chlorideHCID 707665-Aminoisoquinoline

Product 1

HCID 8763095HCID 8763095, compound

Procedure

Anisoyl chloride was reacted with 5-aminoisoquinoline according to the procedure of Example 8 to produce 5-(4-methoxybenzamido) isoquinoline. This product was then reduced according to the procedure of Example 8 to yield 5-(4-methoxybenzamido)-1,2,3,4-tetrahydroisoquinoline HCl. After purification from water it had a melting point of 289°-290° C.

Sources & evidence

ORD record
ord-82b4a9e019b44c63bfdee6a4202217cd
Source dataset
uspto-grants-1977_05
Patent number
US04022900

Reaction notes

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