2-Nitrobenzoyl chloride → Benzamide, 2-nitro-N-(1,2,3,4-tetrahydro-2-methylisoquinolin-5-yl)-

HRID 2397945Notes

Reaction equation

HRID 2397945 reaction equation
[NH2:1][C:2]1[CH:11]=[CH:10][CH:9]=[C:8]2[C:3]=1[CH2:4][CH2:5][N:6]([CH3:12])[CH2:7]2.[N+:13]([C:16]1[CH:24]=[CH:23][CH:22]=[CH:21][C:17]=1[C:18](Cl)=[O:19])([O-:15])=[O:14]>>[N+:13]([C:16]1[CH:24]=[CH:23][CH:22]=[CH:21][C:17]=1[C:18]([NH:1][C:2]1[CH:11]=[CH:10][CH:9]=[C:8]2[C:3]=1[CH2:4][CH2:5][N:6]([CH3:12])[CH2:7]2)=[O:19])([O-:15])=[O:14]

Participants

3

Reactant 2

HCID 118752-Nitrobenzoyl chlorideHCID 141712692-Methyl-1,2,3,4-tetrahydroisoquinolin-5-amine

Product 1

HCID 216599Benzamide, 2-nitro-N-(1,2,3,4-tetrahydro-2-methylisoquinolin-5-yl)-

Procedure

5-Amino-2-methyl-1,2,3,4-tetrahydroisoquinoline was reacted with 2-nitrobenzoyl chloride according to the procedure of Example 19 to yield 5-(2-nitrobenzamido) -2-methyl - 1,2,3,4-tetrahydroisoquinoline; m.p. 196.5°-198° C. after purification from ethanol.

Sources & evidence

ORD record
ord-c22983bfead948f797c9205080000601
Source dataset
uspto-grants-1977_05
Patent number
US04022900

Reaction notes

Loading…