Benzoyl chloride → HCID 70634974, compound

HRID 2397956Notes

Reaction equation

HRID 2397956 reaction equation
[OH:1][C@@H:2]1[C@@:27]2([CH3:28])[C:6](=[CH:7][CH:8]=[C:9]3[C@@H:26]2[CH2:25][CH2:24][C@@:23]2([CH3:29])[C@H:10]3[CH2:11][CH2:12][C@@H:13]2[C@H:14]([CH3:22])[CH2:15][CH2:16][CH:17]([OH:21])[CH:18]([CH3:20])[CH3:19])[CH2:5][C@@H:4]([OH:30])[CH2:3]1.[C:31](Cl)(=[O:38])[C:32]1[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=1>N1C=CC=CC=1>[OH:1][C@@H:2]1[C@@:27]2([CH3:28])[C:6](=[CH:7][CH:8]=[C:9]3[C@@H:26]2[CH2:25][CH2:24][C@@:23]2([CH3:29])[C@H:10]3[CH2:11][CH2:12][C@@H:13]2[C@H:14]([CH3:22])[CH2:15][CH2:16][CH:17]([O:21][C:31](=[O:38])[C:32]2[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=2)[CH:18]([CH3:20])[CH3:19])[CH2:5][C@@H:4]([O:30][C:2](=[O:1])[C:27]2[CH:6]=[CH:7][CH:8]=[CH:9][CH:26]=2)[CH2:3]1

Participants

4

Reactant 2

HCID 7412Benzoyl chlorideHCID 13341408HCID 13341408, compound

Product 1

HCID 70634974HCID 70634974, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

250 mg of 1α,3β,24-trihydroxycholesta-5,7-diene prepared in the same way as in Example 14, (D-1) was mixed with 210 mg of benzoyl chloride and 5 ml. of pyridine, and the mixture was allowed to stand at 23° C. for one day. The resulting reaction mixture was treated in the same way as in Example 21 to afford 1α-hydroxy-3β,24-dibenzoyloxycholesta-5,7-diene.

Workup

  1. customThe resulting reaction mixture
  2. additionwas treated in the same way as in Example 21

Sources & evidence

ORD record
ord-149df504265147ebab88d73d036a45de
Source dataset
uspto-grants-1977_05
Patent number
US04022891

Reaction notes

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