HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2397975Generated: October 29, 2026
Sodium Sulfite → 1alpha-Methyl-4-androstene-17,19-dione
https://huagongshe.com/reaction/2397975
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Sodium Sulfite | HCID 24437 | — |
| Reactant | 1alpha-Methyl-4-androstene-17beta,19-diol | HCID 70584758 | — |
| Reactant | Jones' reagent | HCID 131709961 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 1alpha-Methyl-4-androstene-17,19-dione | HCID 53781675 | — |
Reaction Steps
1α-Methyl-4-androstene-17β,19-diol is dissolved in dimethylformamide at 40° C. and two equivalents of Jones Reagent are added all at once. The mixture is stirred for about 5 hours at 40° C., cooled and a 1% aqueous sodium sulfite solution is added. After several hours the crystals which form are collected by filtration, thoroughly washed with water and air dried. Crystallization from hexane yields the desired 1α-methyl-4-androstene-17,19-dione.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US04022769 |
|---|
| Source dataset | uspto-grants-1977_05 |
|---|
| ORD ID | ord-2fa7a460882c4a3f94cde76f0db349b7 |
|---|
| Source note | uspto-grants-1977_05 |
|---|
