1alpha-Methyl-17beta-trimethylsiloxy-4-androsten-19-one → 17beta-Trimethylsiloxy-4-androsten-19-one

HRID 2397982Notes

Reaction equation

HRID 2397982 reaction equation
O[C@H]1CC[C@H]2[C@H]3[C@H](CC[C@]12C)[C@]1(C=O)C(=CCCC1)CC3.C[C@@H:23]1[C@@:40]2([CH:41]=[O:42])[C:27]([CH2:28][CH2:29][C@@H:30]3[C@@H:39]2[CH2:38][CH2:37][C@@:35]2([CH3:36])[C@H:31]3[CH2:32][CH2:33][C@@H:34]2[O:43][Si:44]([CH3:47])([CH3:46])[CH3:45])=[CH:26][CH2:25][CH2:24]1>>[CH3:46][Si:44]([CH3:45])([CH3:47])[O:43][C@H:34]1[CH2:33][CH2:32][C@H:31]2[C@H:30]3[C@H:39]([CH2:38][CH2:37][C@:35]12[CH3:36])[C@:40]1([CH:41]=[O:42])[C:27](=[CH:26][CH2:25][CH2:24][CH2:23]1)[CH2:28][CH2:29]3

Participants

3

Reactant 2

HCID 227974621alpha-Methyl-17beta-trimethylsiloxy-4-androsten-19-oneHCID 5429705217beta-Hydroxy-4-androsten-19-one

Product 1

HCID 2279744617beta-Trimethylsiloxy-4-androsten-19-one

Procedure

Substituting 17β-hydroxy-4-androsten-19-one for the 17β-hydroxy-1α-methyl-4-androsten-19-one above results in the formation of 17β-trimethylsiloxy-4-androsten-19-one.

Sources & evidence

ORD record
ord-34e2c159806d45548f5a27fe0a301d71
Source dataset
uspto-grants-1977_05
Patent number
US04022769

Reaction notes

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