Androsta-1,4-diene-3,17-dione → 1,5-Androstadiene-3,17-dione

HRID 2397983Notes

Reaction equation

HRID 2397983 reaction equation
CC(C)([O-])C.[K+].[CH3:7][C@:8]12[CH2:25][CH2:24][C@H:23]3[C@@H:13]([CH2:14][CH2:15][C:16]4[C@:21]3([CH3:22])[CH:20]=[CH:19][C:18](=[O:26])[CH:17]=4)[C@@H:12]1[CH2:11][CH2:10][C:9]2=[O:27].[Cl-].[NH4+]>CS(C)=O>[CH3:7][C@:8]12[CH2:25][CH2:24][C@H:23]3[C@@H:13]([CH2:14][CH:15]=[C:16]4[C@:21]3([CH3:22])[CH:20]=[CH:19][C:18](=[O:26])[CH2:17]4)[C@@H:12]1[CH2:11][CH2:10][C:9]2=[O:27]

Participants

5

Reactant 3

HCID 13472Androsta-1,4-diene-3,17-dioneHCID 25517Ammonium ChlorideHCID 23665647Potassium tert-butoxide

Product 1

HCID 572670321,5-Androstadiene-3,17-dione

Reagents, catalysts & solvents 1

HCID 679Dimethyl SulfoxideSolvent2×

Procedure

To a solution of potassium t-butoxide in dimethylsulfoxide at 25° C. under nitrogen is added 1,4-androstadiene-3,17-dione in dimethylsulfoxide with stirring. After a period of 15 minutes the mixture is poured onto a cold aqueous ammonium chloride solution. The solid is rapidly filtered, washed well with water and dissolved in ether. The ether solution is washed with water, dried over sodium sulfate and evaporated at room temperature to yield 1,5-androstadiene-3,17-dione.

Workup

  1. filtrationThe solid is rapidly filtered
  2. washwashed well with water
  3. dissolutiondissolved in ether
  4. washThe ether solution is washed with water
  5. dry with materialdried over sodium sulfate
  6. customevaporated at room temperature

Sources & evidence

ORD record
ord-b2a0dccd125c40fd8a6b588f11e7389e
Source dataset
uspto-grants-1977_05
Patent number
US04022769

Reaction notes

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