HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetic Acid → 1beta-Methyl-4-androstene-3,17-dione
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetic Acid | HCID 176 | — |
| Reactant | 1beta,2beta-Methylene-4-androstene-3,17-dione | HCID 54262378 | — |
| Catalyst | Zinc | HCID 23994 | — |
| Solvent | Benzene | HCID 241 | — |
| Product | 1beta-Methyl-4-androstene-3,17-dione | HCID 54175784 | — |
Reaction Steps
1β,2β-Methylene-4-androstene-3,17-dione, zinc powder, and acetic acid are refluxed for about one hour. Benzene is added, the suspension filtered and the filtrate taken to dryness under vacuum. The residue is chromatographed on silica gel and eluted with methylenechloride. Recrystallization from acetone-hexane yields 1β-methyl-4-androstene-3,17-dione.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04022769 |
| Source dataset | uspto-grants-1977_05 |
| ORD ID | ord-d75573b62a85496ab823980756c7e619 |
| Source note | uspto-grants-1977_05 |