Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Sodium Sulfite | HCID 24437 | — |
| Reactant | 19-Hydroxy-6alpha-methyl-4-androstene-3,17-dione | HCID 70583925 | — |
| Reactant | Jones' reagent | HCID 131709961 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 54306672 | HCID 54306672 | — |
Reaction Steps
To a solution of 19-hydroxy-6α-methyl-4-androstene-3,17-dione in dimethylformamide at 40° C. is rapidly added one equivalent of Jones Reagent. The solution is stirred for about 5 hours at 40° C., cooled and a 1% aqueous sodium sulfite solution is added. The precipitate which forms is collected, washed well with water and crystallized from ether-hexane to yield 6α-methyl-4-androstene-3,17,19-trione.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US04022769 |
|---|
| Source dataset | uspto-grants-1977_05 |
|---|
| ORD ID | ord-f48960192fc54a9caaec8d84964d65f4 |
|---|
| Source note | uspto-grants-1977_05 |
|---|
