19-Hydroxyandrostenedione → 19-Hydroxy-4,7alpha-dimethyl-4-androstene-3,17-dione

HRID 2398003노트

반응식

HRID 2398003 반응식
[OH:1][CH2:2][C@@:3]12[C@@H:20]3[C@H:11]([C@H:12]4[C@@:16]([CH2:18][CH2:19]3)([CH3:17])[C:15](=[O:21])[CH2:14][CH2:13]4)[C@H:10]([CH3:22])[CH2:9][C:8]1=[CH:7][C:6](=[O:23])[CH2:5][CH2:4]2.[OH:24][CH2:25][C@@:26]12[C@@H:43]3[C@H:34]([C@H:35]4[C@@:39]([CH2:41][CH2:42]3)([CH3:40])[C:38](=[O:44])[CH2:37][CH2:36]4)[CH2:33][CH2:32][C:31]1=[CH:30][C:29](=[O:45])[CH2:28][C@@H:27]2[CH3:46].O[CH2:48][C@@]12[C@@H]3[C@H]([C@H]4[C@@](CC3)(C)C(=O)CC4)CCC1=CC(=O)CC2>>[OH:1][CH2:2][C@@:3]12[C@@H:20]3[C@H:11]([C@H:12]4[C@@:16]([CH2:18][CH2:19]3)([CH3:17])[C:15](=[O:21])[CH2:14][CH2:13]4)[C@H:10]([CH3:22])[CH2:9][C:8]1=[C:7]([CH3:25])[C:6](=[O:23])[CH2:5][CH2:4]2.[OH:24][CH2:25][C@@:26]12[C@@H:43]3[C@H:34]([C@H:35]4[C@@:39]([CH2:41][CH2:42]3)([CH3:40])[C:38](=[O:44])[CH2:37][CH2:36]4)[CH2:33][CH2:32][C:31]1=[C:30]([CH3:48])[C:29](=[O:45])[CH2:28][C@@H:27]2[CH3:46]

참가 물질

5

반응물 3

HCID 25237919-HydroxyandrostenedioneHCID 5433255619-Hydroxy-7alpha-methyl-4-androstene-3,17-dioneHCID 7058400819-Hydroxy1alpha-methyl-4-androstene-3,17-dione

생성물 2

HCID 5411425419-Hydroxy-4,7alpha-dimethyl-4-androstene-3,17-dioneHCID 7058545619-Hydroxy-1alpha,4-dimethyl-4-androstene-3,17-dione

실험 절차

Substituting 19-hydroxy-7α-methyl-4-androstene-3,17-dione and 19-hydroxy-1α-methyl-4-androstene-3,17-dione for the 19-hydroxy-4-androstene-3,17-dione above results in the preparation of 19-hydroxy-4,7α-dimethyl-4-androstene-3,17-dione and 19-hydroxy-1α,4-dimethyl-4-androstene-3,17-dione.

출처 및 근거

ORD 기록
ord-63dd8a09ef514475936e7ccefe761ed2
출처 데이터셋
uspto-grants-1977_05
특허 번호
US04022769

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