Guanidine → 5-[(4-Chloro-3,5-dimethoxyphenyl)methyl]pyrimidine-2,4-diamine

Participants

Reaction Steps

21 G. of 4-chloro-3,5-dimethoxy-α -cyano-hydrocinnamaldehyde dimethyl acetal were heated to reflux for 1.5 hours with 140 ml. of a 1N methanolic guanidine solution. The solvent was then removed by distillation on an oil bath at 160° C. and the residue heated for 15-20 minutes at this temperature until completely solidified to a crystalline mass. The mass was slurried with 80-100 ml. of water and removed by filtration under suction, whereby there was obtained 2,4-diamino-5-(4-chloro-3,5-dimethoxybenzyl)-pyrimidine of melting point 218° C.

Provenance & Evidence