Hydrochloric Acid → HCID 21434698, compound

Participants

Reaction Steps

A solution of 38 g. (0.227 mole) of the hydrochloride of benzimidic acid phenyl hydrazide, 25 ml. (0.166 mole) of α-chloroformyl acetic acid ethyl ester and 47.5 ml. (0.335 mole) of triethylamine in 420 ml. of methylene chloride is kept at room temperature for about 3 hours, and to it is subsequently added a solution of 38 ml. (0.271 mole) of triethylamine and 25 ml. (0.166 mole) of α-chloroformyl acetic acid ethyl ester in 30 ml. of methylene chloride. The resulting mixture is stirred for about 4 hours and allowed to stand overnight at room temperature. 48 Grams of the crude intermediate compound of formula V, namely 5-carbethoxymethyl-1,3-diphenyl-1,2,4-triazole is so obtained, which is used as such for the subsequent hydrolysis step.

Provenance & Evidence