Acetic Anhydride → HCID 21434699, compound

HRID 2398080Notes

Reaction equation

HRID 2398080 reaction equation
[OH:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[N:5]2[N:12]=[C:13]([C:15]3[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=3)[N:14]=[C:4]2[CH:3]=1.[C:21](OC(=O)C)(=[O:23])[CH3:22]>N1C=CC=CC=1>[C:21]([O:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[N:5]2[N:12]=[C:13]([C:15]3[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=3)[N:14]=[C:4]2[CH:3]=1)(=[O:23])[CH3:22]

Participants

4

Reactant 2

HCID 7918Acetic AnhydrideHCID 178515399HCID 178515399, compound

Product 1

HCID 21434699HCID 21434699, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

0.8 Gram (0.00306 mole) of the compound of Example 1 is dissolved in 10 ml. of pyridine, then 1 ml. of acetic acid anhydride is added and the resulting mixture is kept at room temperature for about 12 hours. The obtained precipitate is purified by column chromatography and eluting with a mixture of chloroform:methanol=98.2. After recrystallization from a mixture of methanol and methylene chloride, 0.200 g. of the title compound is obtained, m.p. 200°-202° C.

Workup

  1. customThe obtained precipitate is purified by column chromatography
  2. washeluting with a mixture of chloroform
  3. customAfter recrystallization
  4. additionfrom a mixture of methanol and methylene chloride, 0.200 g

Sources & evidence

ORD record
ord-fa425f9e34fc45da902b450591b0afeb
Source dataset
uspto-grants-1977_05
Patent number
US04024149

Reaction notes

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