Triethylamine → HCID 54140071, compound

Participants

Reaction Steps

To a solution of 9 g of 5-nitro-2-furaldehyde and 11.0 g of 2-chloropropionyl chloride in 100 ml of benzene was added dropwise at 25°-30° over a 20-minute period a solution of 10 g of triethylamine in 30 ml of benzene. After an additional 40 minutes, the mixture was stirred at reflux for 1.5 hours. The cooled mixture was washed with water, dried and concentrated under reduced pressure to leave a residue which was distilled to give a liquid product, b.p.: 92°-100° at 0.15 torr. This product was triturated with n-hexane to give 3 as a mixture of stereisomers, a tan solid, m.p.: 55°-65°.

Provenance & Evidence