Sodium Nitrite → t-Butyl 3-acetoxymethyl-7beta-[2-hydroxyimino(pyrid-4-yl)acetamido]-ceph-3-em-4-carboxylate

HRID 2398157Notes

Reaction equation

HRID 2398157 reaction equation
[C:1]([O:4][CH2:5][C:6]1[CH2:7][S:8][C@@H:9]2[C@H:20]([NH:21][C:22](=[O:30])[CH2:23][C:24]3[CH:29]=[CH:28][N:27]=[CH:26][CH:25]=3)[C:19](=[O:31])[N:10]2[C:11]=1[C:12]([O:14][C:15]([CH3:18])([CH3:17])[CH3:16])=[O:13])(=[O:3])[CH3:2].[N:32]([O-])=[O:33].[Na+]>C(O)(=O)C.O.CC(C)=O>[C:1]([O:4][CH2:5][C:6]1[CH2:7][S:8][C@@H:9]2[C@H:20]([NH:21][C:22](=[O:30])[C:23]([C:24]3[CH:25]=[CH:26][N:27]=[CH:28][CH:29]=3)=[N:32][OH:33])[C:19](=[O:31])[N:10]2[C:11]=1[C:12]([O:14][C:15]([CH3:16])([CH3:18])[CH3:17])=[O:13])(=[O:3])[CH3:2]

Participants

6

Reactant 2

HCID 23668193Sodium NitriteHCID 131710773t-Butyl 3-acetoxymethyl-7beta-(pyrid-4-ylacetamido)ceph-3-em-4-carboxylate

Product 1

HCID 137195895t-Butyl 3-acetoxymethyl-7beta-[2-hydroxyimino(pyrid-4-yl)acetamido]-ceph-3-em-4-carboxylate

Reagents, catalysts & solvents 3

HCID 176Acetic AcidSolventHCID 180AcetoneSolventHCID 962WaterSolvent2×

Procedure

A solution of t-butyl 3-acetoxymethyl-7β-(pyrid-4-ylacetamido)ceph-3-em-4-carboxylate (3.0 g.) in acetic acid (30 ml.) was stirred, cooled briefly in ice and treated dropwise over 3-4 minutes with a solution of sodium nitrite (1.38 g.), in water (10 ml.). The mixture was stirred at 20° for 30 minutes and was then diluted with water and extracted with ethyl acetate. The organic extract was washed with saturated sodium bicarbonate solution and water and then dried over magnesium sulphate. Evaporation almost to dryness gave a residue which was dissolved in the minimum volume of acetone and added dropwise to stirred petroleum spirit (bp. 40°-60°). The resulting solid was collected, washed with petroleum spirit and dried to yield the title oxime as a white powder (2.9 g., 91%) which was shown (NMR) to be a syn-/anti-mixture (30:/0).

Workup

  1. temperaturecooled briefly in ice
  2. extractionextracted with ethyl acetate
  3. extractionThe organic extract
  4. washwas washed with saturated sodium bicarbonate solution and water
  5. dry with materialdried over magnesium sulphate
  6. customEvaporation almost to dryness
  7. customgave a residue which
  8. additionadded dropwise
  9. customThe resulting solid was collected
  10. washwashed with petroleum spirit
  11. customdried

Sources & evidence

ORD record
ord-de52d507d6ab4ffb99ac25dce598ed4c
Source dataset
uspto-grants-1977_05
Patent number
US04024134

Reaction notes

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