Cyclohexyl isocyanate → HCID 21434457, compound

HRID 2398161Notes

Reaction equation

[CH2:1]([N:3]([CH2:21][CH3:22])[C:4]([N:6]1[CH2:12][CH2:11][C:10]2[CH:13]=[CH:14][C:15]([S:17]([NH2:20])(=[O:19])=[O:18])=[CH:16][C:9]=2[CH2:8][CH2:7]1)=[O:5])[CH3:2].[CH:23]1([N:29]=[C:30]=[O:31])[CH2:28][CH2:27][CH2:26][CH2:25][CH2:24]1>>[CH:23]1([NH:29][C:30]([NH:20][S:17]([C:15]2[CH:14]=[CH:13][C:10]3[CH2:11][CH2:12][N:6]([C:4](=[O:5])[N:3]([CH2:1][CH3:2])[CH2:21][CH3:22])[CH2:7][CH2:8][C:9]=3[CH:16]=2)(=[O:18])=[O:19])=[O:31])[CH2:28][CH2:27][CH2:26][CH2:25][CH2:24]1

Participants

Reactant 2

HCID 18502Cyclohexyl isocyanate

HCID 21434445HCID 21434445, compound

Product 1

HCID 21434457HCID 21434457, compound

Procedure

In a manner analogous to that described in Example 1, from 3-diethylcarbamoyl-2,3,4,5-tetrahydro-1H-3-benzazepine-7-sulfonamide and cyclohexylisocyanate, there is obtained 1-cyclohexyl-3-[(3-diethylcarbamoyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)sulfonyl]urea, m.p. 168°-169° C. The starting material can be prepared by the reaction of 2,3,4,5-tetrahydro-1H-3-benzazepine-7-sulfonamide hydrochloride with diethylcarbamoyl chloride in a manner analogous to that described in Example 1.

Sources & evidence

ORD record: ord-19c050915499465eb940d87f3c5da0a9
Source dataset: uspto-grants-1977_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04024128

Reaction notes

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