Cyclohexyl isocyanate → HCID 21434446, compound

HRID 2398162Notes

Reaction equation

[CH2:1]([N:4]([CH2:22][CH2:23][CH3:24])[C:5]([N:7]1[CH2:13][CH2:12][C:11]2[CH:14]=[CH:15][C:16]([S:18]([NH2:21])(=[O:20])=[O:19])=[CH:17][C:10]=2[CH2:9][CH2:8]1)=[O:6])[CH2:2][CH3:3].[CH:25]1([N:31]=[C:32]=[O:33])[CH2:30][CH2:29][CH2:28][CH2:27][CH2:26]1>>[CH:25]1([NH:31][C:32]([NH:21][S:18]([C:16]2[CH:15]=[CH:14][C:11]3[CH2:12][CH2:13][N:7]([C:5](=[O:6])[N:4]([CH2:1][CH2:2][CH3:3])[CH2:22][CH2:23][CH3:24])[CH2:8][CH2:9][C:10]=3[CH:17]=2)(=[O:20])=[O:19])=[O:33])[CH2:30][CH2:29][CH2:28][CH2:27][CH2:26]1

Participants

Reactant 2

HCID 18502Cyclohexyl isocyanate

HCID 21434439HCID 21434439, compound

Product 1

HCID 21434446HCID 21434446, compound

Procedure

In a manner analogous to that described in Example 1, from 3-dipropylcarbamoyl-2,3,4,5-tetrahydro-1H-3-benzazepine-7-sulfonamide and cyclohexylisocyanate, there is obtained 1-cyclohexyl-3-[(3-dipropylcarbamoyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)sulfonyl]urea, m.p. 179°-180° C. The starting material can be prepared by the reaction of 2,3,4,5-tetrahydro-1H-3-benzazepine-7-sulfonamide hydrochloride with dipropylcarbamoyl chloride in a manner analogous to that described in Example 1.

Sources & evidence

ORD record: ord-81176b2ff7374916a328f9a77b3f9489
Source dataset: uspto-grants-1977_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04024128

Reaction notes

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