Butyl isocyanate → 1-butyl-3-[(3-dimethylcarbamoyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl) sulfonyl]urea

HRID 2398164Notes

Reaction equation

[CH3:1][N:2]([CH3:20])[C:3]([N:5]1[CH2:11][CH2:10][C:9]2[CH:12]=[CH:13][C:14]([S:16]([NH2:19])(=[O:18])=[O:17])=[CH:15][C:8]=2[CH2:7][CH2:6]1)=[O:4].[CH2:21]([N:25]=[C:26]=[O:27])[CH2:22][CH2:23][CH3:24]>>[CH2:21]([NH:25][C:26]([NH:19][S:16]([C:14]1[CH:13]=[CH:12][C:9]2[CH2:10][CH2:11][N:5]([C:3](=[O:4])[N:2]([CH3:20])[CH3:1])[CH2:6][CH2:7][C:8]=2[CH:15]=1)(=[O:18])=[O:17])=[O:27])[CH2:22][CH2:23][CH3:24]

Participants

Reactant 2

HCID 8110Butyl isocyanate

HCID 21434451HCID 21434451, compound

Product 1

HCID 536983441-butyl-3-[(3-dimethylcarbamoyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl) sulfonyl]urea

Procedure

By the reaction of 3-dimethylcarbamoyl-2,3,4,5-tetrahydro-1H-3-benzazepine-7-sulfonamide with butylisocyanate in a manner analogous to that described in Example 1, there is obtained 1-butyl-3-[(3-dimethylcarbamoyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl) sulfonyl]urea, m.p. 93° C. (with decomposition).

Sources & evidence

ORD record: ord-05af23ad6c4e4c6caa8a16023aea5529
Source dataset: uspto-grants-1977_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04024128

Reaction notes

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