Cyclohexyl isocyanate → HCID 21434462, compound

HRID 2398166Notes

Reaction equation

[N:1]1([C:7]([N:9]2[CH2:15][CH2:14][C:13]3[CH:16]=[CH:17][C:18]([S:20]([NH2:23])(=[O:22])=[O:21])=[CH:19][C:12]=3[CH2:11][CH2:10]2)=[O:8])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[CH:24]1([N:30]=[C:31]=[O:32])[CH2:29][CH2:28][CH2:27][CH2:26][CH2:25]1>>[CH:24]1([NH:30][C:31]([NH:23][S:20]([C:18]2[CH:17]=[CH:16][C:13]3[CH2:14][CH2:15][N:9]([C:7]([N:1]4[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]4)=[O:8])[CH2:10][CH2:11][C:12]=3[CH:19]=2)(=[O:22])=[O:21])=[O:32])[CH2:29][CH2:28][CH2:27][CH2:26][CH2:25]1

Participants

Reactant 2

HCID 18502Cyclohexyl isocyanate

HCID 21434442HCID 21434442, compound

Product 1

HCID 21434462HCID 21434462, compound

Procedure

By the reaction of 2,3,4,5-tetrahydro-3-(1-piperidinylcarbonyl)-1H-3-benzazepine-7-sulfonamide with cyclohexylisocyanate in a manner analogous to that described in Example 1, there is obtained 1-cyclohexyl-3-{[2,3,4,5-tetrahydro-3-(1-piperidinylcarbonyl)-1H-3-benzazepin-7-yl]sulfonyl}urea, m.p. 166°-167° C. The starting material can be prepared by the reaction of 2,3,4,5-tetrahydro-1H-3-benzazepine-7-sulfonamide hydrochloride with 1-piperidine-carbonyl chloride in a manneranalogous to that described in Example 1.

Sources & evidence

ORD record: ord-26ae737ca68b47bd9241ca0c5c6e30e5
Source dataset: uspto-grants-1977_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04024128

Reaction notes

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