Cyclohexyl isocyanate → HCID 21434453, compound

HRID 2398171Notes

Reaction equation

[CH:1]([NH:4][C:5]([N:7]1[CH2:13][CH2:12][C:11]2[CH:14]=[CH:15][C:16]([S:18]([NH2:21])(=[O:20])=[O:19])=[CH:17][C:10]=2[CH2:9][CH2:8]1)=[O:6])([CH3:3])[CH3:2].[CH:22]1([N:28]=[C:29]=[O:30])[CH2:27][CH2:26][CH2:25][CH2:24][CH2:23]1>>[CH:22]1([NH:28][C:29]([NH:21][S:18]([C:16]2[CH:15]=[CH:14][C:11]3[CH2:12][CH2:13][N:7]([C:5](=[O:6])[NH:4][CH:1]([CH3:3])[CH3:2])[CH2:8][CH2:9][C:10]=3[CH:17]=2)(=[O:20])=[O:19])=[O:30])[CH2:27][CH2:26][CH2:25][CH2:24][CH2:23]1

Participants

Reactant 2

HCID 18502Cyclohexyl isocyanate

HCID 21434437HCID 21434437, compound

Product 1

HCID 21434453HCID 21434453, compound

Procedure

By the reaction of 3-isopropylcarbamoyl-2,3,4,5-tetrahydro-1H-3-benzazepine-7-sulfonamide with cyclohexylisocyanate in a manner analogous to that described in Example 1, there is obtained 1-cyclohexyl-3-[(3-isopropylcarbamoyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)sulfonyl]urea. The starting material can be prepared by the reaction of 2,3,4,5-tetrahydro-1H-3-benzazepine-7-sulfonamide with isopropylisocyanate in a manner analogous to that described in Example 8.

Sources & evidence

ORD record: ord-6a8f7bcb409e4cec952d34ad6634ea10
Source dataset: uspto-grants-1977_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04024128

Reaction notes

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