Cyclohexyl isocyanate → HCID 21434435, compound

HRID 2398176Notes

Reaction equation

[O:1]1[CH2:6][CH2:5][N:4]([C:7]([N:9]2[CH2:15][CH2:14][C:13]3[CH:16]=[CH:17][C:18]([S:20]([NH2:23])(=[O:22])=[O:21])=[CH:19][C:12]=3[CH2:11][CH2:10]2)=[O:8])[CH2:3][CH2:2]1.[CH:24]1([N:30]=[C:31]=[O:32])[CH2:29][CH2:28][CH2:27][CH2:26][CH2:25]1>>[CH:24]1([NH:30][C:31]([NH:23][S:20]([C:18]2[CH:17]=[CH:16][C:13]3[CH2:14][CH2:15][N:9]([C:7]([N:4]4[CH2:5][CH2:6][O:1][CH2:2][CH2:3]4)=[O:8])[CH2:10][CH2:11][C:12]=3[CH:19]=2)(=[O:22])=[O:21])=[O:32])[CH2:29][CH2:28][CH2:27][CH2:26][CH2:25]1

Participants

Reactant 2

HCID 18502Cyclohexyl isocyanate

HCID 21434450HCID 21434450, compound

Product 1

HCID 21434435HCID 21434435, compound

Procedure

By the reaction of 2,3,4,5-tetrahydro-3-morpholinocarbonyl-1H-3-benzazepine-7-sulfonamide with cyclohexylisocyanate in a manner analogous to that described in Example 1, there is obtained 1-cyclohexyl-3-[(2,3,4,5-tetrahydro-3-morpholinocarbonyl-1H-3-benzazepin-7-yl)sulfonyl]urea, m.p. 190°-191° C. The starting material can be prepared by the reaction of 2,3,4,5-tetrahydro-1H-3-benzazepine-7-sulfonamide with 4-morpholinecarbonyl chloride.

Sources & evidence

ORD record: ord-e6d0fcf51f324e7e975197390ccc17d1
Source dataset: uspto-grants-1977_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04024128

Reaction notes

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