Phosgene → 1-cyclohexyl-3-{[3-[3,6-dihydro-1(2H)-pyridinecarbonyl]-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl]sulfonyl}urea

Participants

Reaction Steps

By the reaction of 3-[3,6-dihydro-1(2H)-pyridinecarbonyl]-2,3,4,5-tetrahydro-1H-3benzazepine-7-sulfonamide with cyclohexylisocyanate in a manner analogous to that described in Example 1, there is obtained 1-cyclohexyl-3-{[3-[3,6-dihydro-1(2H)-pyridinecarbonyl]-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl]-sulfony(} urea, m.p. 173°-174° C. The starting material can be prepared by first reacting 1,2,3,6-tetrahydropyridine with phosgene and subsequently bringing the resulting 3,6-dihydro-1(2H)-pyridinecarbonyl chloride to reaction with 2,3,4,5-tetrahydro-1H-3-benzazepine-7-sulfonamide hydrochloride.

Provenance & Evidence