4-Chlorophenyl Isocyanate → HCID 54417556, compound

HRID 2398193Notes

Reaction equation

HRID 2398193 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]=[C:9]=[O:10])=[CH:4][CH:3]=1.[CH2:11]([NH:15][C:16]([NH:18][C:19]1[CH:24]=[CH:23][CH:22]=[C:21]([NH2:25])[CH:20]=1)=[S:17])[CH:12]([CH3:14])[CH3:13]>C(Cl)(Cl)Cl>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:9](=[O:10])[NH:25][C:21]2[CH:22]=[CH:23][CH:24]=[C:19]([NH:18][C:16]([NH:15][CH2:11][CH:12]([CH3:14])[CH3:13])=[S:17])[CH:20]=2)=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 76934-Chlorophenyl IsocyanateHCID 21434867HCID 21434867, compound

Product 1

HCID 54417556HCID 54417556, compound

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent2×

Procedure

A solution of freshly distilled p-chlorophenyl isocyanate (1.38 g.) in 10 ml. chloroform is added at room temperature in one portion to a solution of 1-isobutyl-3-(m-aminophenyl)thiourea (2.0 g.) in chloroform (30 ml.). The product precipitates rapidly and is filtered off after several hours. The filter cake is washed with chloroform and dried to give 1-(3-p-chlorophenylureido)-3-(3-isobutylthioureido)-benzene, m.p. 195°-196° C.

Workup

  1. customThe product precipitates rapidly
  2. filtrationis filtered off after several hours
  3. washThe filter cake is washed with chloroform
  4. customdried

Sources & evidence

ORD record
ord-ce3b4cb807b248e29e8ed9e2c0e5d500
Source dataset
uspto-grants-1977_05
Patent number
US04024183

Reaction notes

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