反应详情

A solution of 3-(3-p-chlorophenylureido)aniline (2.0 g.) in pyridine (40 ml.) is stirred at 0° C. with isopropyl isothiocyanate (0.77 ml.). The solution is allowed to warm slowly to room temperature and is stirred for 48 hours. The solution is filtered, the pyridine is removed by distillation under reduced pressure and the residue is crystallized from methanol (300 ml.) to give 1-(3-isopropylthioureido)-3-(3-p-chlorophenylureido)benzene, m.p. 197°-198° C. with decomposition.

1. filtrationThe solution is filtered
2. customthe pyridine is removed by distillation under reduced pressure
3. customthe residue is crystallized from methanol (300 ml.)