4-Chlorophenyl Isocyanate → HCID 178449212, compound

Participants

Reaction Steps

To a solution of 1-isobutyl-3-m-aminophenylguanidine dihydrochloride (19.6 g.) in pyridine (100 ml.) is added dropwise a solution of p-chlorophenyl isocyanate (11.5 g.) in pyridine (25 ml.) at room temperature. The mixture is stirred for 16 hours, and the pyridine is removed by distillation under reduced pressure. The residual gum is shaken with a mixture of ether (100 ml.) and 1% aqueous sodium hydroxide solution (10 ml.) to remove pyridine hydrochloride whereafter the product crystallizes. The solid is filtered off, washed with water and ether and dried, and recrystallized from ethanol/petroleum ether b.p. 40°-60° C. to give 1-(3-isobutylguanidino)-3-(3-p-chlorophenylureido)benzene hydrochloride, m.p. 215°-216° C.

Provenance & Evidence