Sodium Chloride → HCID 131710775, compound

Participants

Reaction Steps

640 mg of 80 % sodium hydride and 6 ml of dimethyl sulfoxide were heated for 1 hour to 65° C and, after cooling to room temperature, 4.7 g of 4-carboxybutyl-triphenylphosphonium-bromide in 8 ml of dimethylsulfoxide under argon were added and stirred for 20 minutes. To the red solution, 1.7 g of [3,3-dimethyl-8-[3-pentyl-3-tetra-hydropyranyloxy-trans-1-propenyl]-1,5-dioxaspiro-[5,4]-dec-7-yl]-acetaldehyde in 4 ml of dimethylsulfoxide were added dropwise and stirred for 15 hours at room temperature. 5% sodium hydrogen sulfate solution was added to that solution until pH 1 was reached, 50 ml of saturated sodium chloride solution were added and the mixture was esterified 3 times with 200 ml of diethyl ether, the combined organic phases were washed with water, dried and condensed.

Provenance & Evidence